Quite naturally, holders of power wish to suppress wild research. Unrestricted questing after knowledge has a long history of producing unwanted competition. The powerful want a “safe line of investigations,” which will develop only those products and ideas that can be controlled and, most important, that will allow the larger part of the benefits to be captured by inside investors. Unfortunately, a random universe full of relative variables does not insure such a “safe line of investigations.”

Assessment of Ix, Bene Gesserit Archives
Frank Herbert, Heretics of Dune